Twin Study Find Cannabis Legalization Linked to Increased Marijuana Use in Adults

PainRelief.com Interview with:
Stephanie Zellers
Psychology
University of Minnesota

PainRelief.com: What is the background for this study?

Response: Many cross-sectional studies have found increases in adult cannabis consumption after the passage of recreational cannabis legalization. These studies, in large population samples across the USA, provide information about possible effects of recreational legalization in representative samples, but cannot draw causally informative conclusions. There are many confounders, like genes, pre-existing differences, and secular trends, that could be alternative explanations for any effects identified.

We utilized a longitudinal twin study to rule out many additional unmeasured confounds shared within families, like genes and aspects of the rearing environment. Importantly, we have data on identical twins before and after recreational legalization, and we have pairs where one twin lives in a recreationally legal state while their co-twin does not. By comparing these twins, we can estimate the causal impact of recreational legalization, after controlling for unmeasured confounds shared by individuals in a family.

Medical Marijuana Users Also More Likely to Also Use Tobacco

PainRelief.com Interview with:
Marc L. Steinberg, Ph.D.,
Professor, Department of Psychiatry, Rutgers RWJMS
Director, Doctoral Psychology Internship Program, Rutgers UBHC – Piscataway
Research Lab Website: Tobacco Research & Intervention Lab

Dr. Steinberg

PainRelief.com: What is the background for this study? What are the main findings?

Response: As the use of cannabis for therapeutic purposes (often called ‘medical marijuana’) has grown, my colleague, Dr. Mary Bridgeman, and I became interested in exploring more about the population who use marijuana for therapeutic purposes. My research has historically focused on tobacco use and so that was one issue in particular that we focused on in this study.

We know that individuals who use cannabis, in general, are more likely to smoke, but we did not know if that was also true for those who used cannabis for therapeutic purposes.  

Fewer Synthetic Cannabinoid Poisonings in States with Legalized Medical Marijuana

PainRelief.com Interview with:
Tracy Klein, PhD, ARNP, FAANP, FRE, FAAN
Assistant Director, Center for Cannabis Policy, Research and Outreach
Associate Professor, College of Nursing
Washington State University Vancouver
Vancouver, WA

PainRelief.com: What is the background for this study?

Response: This study evaluates data on illicit synthetic cannabinoid poisonings reported to the National Poison Data System (NPDS) which contains data from 55 poison centers in the US (https://aapcc.org/about/our-members). We correlated the 7600 poisonings reported between 2016 and 2019 with the reporting state’s status of cannabis legalization: restrictive, medical and permissive.

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Higher Potency Cannabis Associated With Greater Risk of Addiction

PainRelief.com Interview with:
Kat Petrilli, PhD Student
Addiction and Mental Health Group (AIM)
Department of Psychology
University of Bath

PainRelief.com:  What is the background for this study? 

cannabis marijuana weed pot

Response: Cannabis is the third most used drug globally, after alcohol and nicotine. Experimental studies show that THC, the main psychoactive component, causes intoxication, cognitive impairments, as well as symptoms of anxiety and psychosis-like experiences and these effects are dose-dependent, which means that higher potency cannabis products (products with high THC concentrations) could increase the risk of harm to cannabis users. 

Previous studies have shown that concentrations of THC in cannabis have increased over the years. In the US and Europe concentrations of THC in cannabis have more than doubled over the past 10 years. In addition, new legal markets have facilitated the appearance of cannabis products with higher potencies than earlier products, such as cannabis concentrates. We also know from previous studies that cannabis use is associated with mental health disorders and 22% of people who use cannabis are estimated to meet the criteria for cannabis use disorder (CUD) or cannabis addiction. 

International increases in cannabis potency and the availability of higher potency cannabis products makes it especially pressing to understand the association of cannabis potency with mental health outcomes. 

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Study Finds Majority of Hemp Products Mislabeled for CBD and/or THC Content

PainRelief.com Interview with:
Tory R. Spindle, Ph.D. 
Assistant Professor
Behavioral Pharmacology Research Unit
Department of Psychiatry and Behavioral Sciences 
Johns Hopkins University School of Medicine

PainRelief.com:  What is the background for this study?  What are the main findings?

Due to recent policy changes, hemp products and anything derived from hemp, including non-THC cannabis constituents such as CBD are now federally legal. As a result, CBD products are now available nation-wide, including in states where cannabis remains illegal. Some prior work had shown oral or vaporized cannabinoid products have poor labeling accuracy, but no one had examined the labeling accuracy of topical cannabinoid products, which are a product category growing in popularity. We purchased 105 topical cannabinoid products (e.g., lotions, creams, gels, patches) from national retailers and online. 

We found that the vast majority of the products were inaccurately labeled for CBD and/or THC and that many of the products had health claims on the label that are not recognized by the FDA, the most common of which was pain/inflammation.

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Preclinical Trial Tests Combination of CBD:THC for Migraine Relief

PainRelief.com Interview with:
Andrew F. Russo, Ph.D.
Professor, Dept. Molecular Physiology and Biophysics
University of Iowa
Iowa City, IA 52242

Dr. Russo

PainRelief.com:  What is the background for this study? 

Response: The company Schedule 1 Therapeutics approached us with an interest in testing a combination of CBD:THC in migraine. We thought the topic had tremendous public interest so we teamed up with them and won grants from the Migraine Research Foundation and from the National Institute on Drug Abuse.  

Real World Study Evaluates Medical Cannabis for Cancer Pain Relief

PainRelief.com Interview with:
David (Dedi) Meiri PhD
Principal Investigato
Laboratory of Cancer Biology and Cannabinoid Research
Technion
Israel Institute of Technology

PainRelief.com:  What is the background for this study? 

Response: We encountered numerous cancer patients that asked us whether medical cannabis treatment can benefit their health, however, while there is a lot of anecdotal evidence regarding the effectiveness of medical cannabis for pain, not much was known regarding its effectiveness in particular for the treatment of cancer-related pain; and there were no validated clinical studies. This motivated us to conduct an organized and thorough study that can serve patients and government ministries alike.

This study, which was conducted by Dr. Joshua Aviram as part of his postdoctoral fellowship, is the first to assess the possible benefits of medical cannabis for cancer-related pain in oncology patients, gathering information from right before they started the treatment and with repeated follow-ups for an extended period of time. Over a span of six months, we investigated the effectiveness and safety of medical cannabis treatment based on sound real-world evidence.

Australian Study Finds Most Medical Cannabis Obtained Without Prescription

PainRelief.com Interview with:
Janni Leung, PhD
National Health and Medical Research Council Emerging Leadership Fellow
National Centre for Youth Substance Use Research (NCYSUR)
The University of Queensland

PainRelief.com:  What is the background for this study? 

Response: It is important to know the prevalence and source of medical cannabis use because non-prescribed use may put individuals at risk.

Many Young Adults and Adolescents Vape Both Tobacco and Cannabis

PainRelief.com Interview with:
Ruoyan Sun PhD
Assistant Professor
School of Public Health
The University of Alabama at Birmingham

PainRelief.com:  What is the background for this study? 

Response: Many people consider vaping as just nicotine vaping, but these vaping devices can be used to vape cannabis as well. We are curious about how many e-cigarette users are vaping cannabis. Using the Population Assessment of Tobacco and Health (PATH) study from 2018 to 2019, we investigated the proportion of current (past 30-day) e-cigarette users (ages 12-24) who vaped cannabis and their frequency of cannabis vaping.  

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About 1/3 North Americans Self Medicate with Cannabis, Mostly for Pain

PainRelief.com Interview with:
Janni Leung, PhD
Senior Research Fellow
National Centre for Youth Substance Use Research (NCYSUR)
The University of Queensland

Dr. Leung

PainRelief.com:  What is the background for this study? 

Response: There is increasing interest in cannabis use for medical reasons, and we want to find out how many people are using it and for what.

PainRelief.com:  What are the main findings?

Response: Almost 1 in 3 of North Americans self-reported that they have used cannabis for medical reasons, with higher use reported by young adults, although chronic conditions are less prevalent in this group.

Most common reasons were to help with pain, sleep, depression and anxiety, but some reported using it to manage their drug or alcohol use and psychosis.

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