PainRelief.com Interview with:
Dr. Hemant Bhargav, MD, PhD
Associate Professor, Department of Integrative Medicine
National Institute of Mental Health and Neurosciences (NIMHANS)
Hosur Main Road, Bengaluru, Karnataka, India 560029

Opioid withdrawal is marked by sympathovagal imbalance, the fight or flight response system of the body remains overactive while its calming system is underactive. This dysregulation contributes to anxiety, poor sleep, pain, and heightened relapse vulnerability. While medications like buprenorphine effectively manage withdrawal symptoms, they do not fully restore this autonomic balance, representing a critical therapeutic gap.

PainRelief.com: What is the background for this study?

Response: Opioid withdrawal is marked by sympathovagal imbalance, the fight or flight response system of the body remains overactive while its calming system is underactive. This dysregulation contributes to anxiety, poor sleep, pain, and heightened relapse vulnerability. While medications like buprenorphine effectively manage withdrawal symptoms, they do not fully restore this autonomic balance, representing a critical therapeutic gap.

Last Updated on January 8, 2026 by PainRelief.com