PainRelief.com Interview with: Richard L. Nahin, MPH, PhD National Center for Complementary and Integrative Health National Institutes of Health, Bethesda, Maryland
PainRelief.com: What is the background for this study?
Response: While there has been extensive research examining the prevalence of chronic pain, far less is known about the incidence of chronic pain. Understanding the incidence of chronic pain is critical to understanding how such pain manifests and evolves over time.
PainRelief.com Interview with: Professor Tamar Pincus PhD Professor in Health Psychology Dean of the Faculty of the Environment and Life Sciences University of Southampton
PainRelief.com: What is the background for this study?
Response:Antidepressants are recommended by guidelines for many chronic pain conditions. The most common prescribed antidepressant in amitriptyline. We carried out the largest and most systematic review of all antidepressants for all pain condition, at any dose, to test whether they were effective at reducing pain, increasing physical function, and improving mood and sleep. We reviewed 176 trials with almost 30,000 participants. We rated each study for its methodology so we could rank each drug according to how much we could be certain of the evidence.
PainRelief.com Interview with: Yiheng Tu CAS Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Department of Psychology University of Chinese Academy of Sciences Beijing, China
PainRelief.com: What is the background for this study?
Response: Chronic pain (CP) is a leading source of disability worldwide. Multisite chronic pain, where pain is experienced in multiple anatomical locations, affects almost half of chronic pain patients and has been found to have a greater burden on patients’ overall health. However, However, it has not been clear whether people with multisite chronic pain suffered from aggravated neurocognitive abnormalities.
PainRelief.com Interview with: Dr Brendon Haslam PhD La Trobe University and The Florey Institute of Neuroscience and Mental Health University of Melbourne On behalf of the research team that is a collaboration of researchers from the University of South Australia, La Trobe University, University of Melbourne and University of California, San Francisco
Dr Haslam PhD
PainRelief.com: What is the background for this study?
Response: People who experience a stroke are three times more likely to experience chronic pain than the general population. Chronic pain following stroke has additional impact on stroke survivors, making it even harder for them to carry out everyday tasks related to their personal care, occupational and recreational activities. As a result, stroke survivors with chronic pain suffer additional disorders of mood, including depression, that further reduce their quality of life beyond that that is caused by the stroke itself.
Unfortunately, there is currently very little evidence to show effective treatments for stroke survivors with chronic pain. This includes the use of medications and other health therapies. In looking to understand chronic pain following stroke, and be able to develop new therapy approaches for this population, we explored how stroke survivors with and without pain perceive their own bodies. For this study, we particularly explored how they perceived their hand size to be.
PainRelief.com Interview with: Alex BrysonPhD Professor of Quantitative Social Science UCL Social Research Institute University College London London
Prof. Bryson
PainRelief.com: What is the background for this study?
Response: The authors were concerned to know more about both the incidence of chronic pain and its implications for health, wellbeing and labour market prospects later in life. So we turned to a birth cohort study (The National Child Development Study) tracking all those born in Britain in a single week in 1958 through to age 62 to take a life-course approach.
PainRelief.com Interview with: Vinod Dasa MD Professor of Clinical Orthopaedics Director of Research Louisiana State University Health
PainRelief.com: Would you describe cryoneurolysis?
Response: Cryoneurolysis is a specialized intense cold therapy technique that provides long-term pain relief without the use of any system drugs. The iovera° system has revolutionized the delivery of long term, drug-free pain relief by delivering a concentrated, targeted cold therapy through a handheld device. The iovera° treatment blocks targeted sensory nerves from sending pain signals. Small closed-end needles are inserted into the treatment region and a treatment cycle is performed until the nerve is blocked, providing pain relief until the nerve regenerates. The localized nerve blocks and targets peripheral nerves to temporarily stop pain signals for up to 90 days and provide immediate, long-lasting pain relief without the need for opioids. The iovera° treatment is used to treat specific nerves so the pain relief is focused only on the part of the body that is being treated.
PainRelief.com Interview with: Wendy C. King, PhD Epidemiology Data Center School of Public Health University of Pittsburgh Pittsburgh, PA
Dr. King
PainRelief.com: What is the background for this study?
Response: Previous studies had provided evidence that bariatric surgical procedures are associated with improvements in pain, physical function and work productivity. However, most prior studies only followed participants 1-2 years, at which point participants were at the peak of their weight loss.
Among a large cohort of US adults, we wanted to evaluate how much initial improvements in pain, physical function and work productivity declined during long-term follow-up, when some degree of weight regain is not uncommon. We limited our study to adults who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG), the two most common bariatric surgical procedures done today.
PainRelief.com Interview with: Eric C. Schwenk MD Anesthesiology Sidney Kimmel Medical College Thomas Jefferson University Philadelphia, Pennsylvania
Dr. Schwent
PainRelief.com: What is the background for this study? What are the main findings?
Response: Patients with refractory chronic migraine (rCM) have typically failed all available medications and many times have nearly constant headache pain and in many cases disability. Aggressive treatment is indicated to provide relief and help break the cycle of pain.
Lidocaine infusions have been used for decades in various acute and chronic pain conditions, including complex regional pain syndrome and pain after surgery. At the Jefferson Headache Center lidocaine has been a mainstay of treatment for such patients for several decades but evidence supporting its benefits is scarce.
The main findings were that patients with rCM experienced acute relief at the end of the infusion and that some relief was sustained at 1 month, although the degree of pain relief faded over time. It was also well tolerated with nausea and vomiting occurring in 16.6% of patients and other side effects occurring less frequently.
PainRelief.com Interview with: Imanuel Lerman MD MSc Associate Professor Affiliate Electrical and Computer Engineering VA San Diego Healthcare System Center for Stress and Mental Health Center for Pain Medicine UC San Diego Health Qualcomm Institute California Institute for Telecommunications and Information Technology (Calit2)
Dr. Lerman
PainRelief.com: What is the background for this study? What are the main findings?
Response:Spinal Cord Stimulation (SCS) offers an implantable, non-pharmacologic treatment for patients with intractable chronic pain conditions. There is extensive clinical literature that offers support for efficacy in chronic pain treatment for both Low frequency and High frequency based spinal cord stimulation. While Low Frequency SCS has been heavily examined since its inception, High Frequency SCS paradigms have recently been clinically approved.
Emerging preclinical work also show sex may alter certain immunological pathways that contribute to chronic pain. But to date few report have identified interactions between sex and SCS. Therefore, we aimed to fill this knowledge gap through a single site (University of California San Diego), large (n=237) retrospective (2004–2020) analyses that compared SCS paradigm Low vs High Frequency SCS, efficacy (pain relief and opiate sparing effects) across sex.
Ms Emma Ho | BAppSc(Phty)(Hons), PhD Candidate The University of Sydney Faculty of Medicine and Health | Charles Perkins Centre Musculoskeletal Research Hub | Sydney NeuroMusculoskeletal Research Collaborative Faculty of Medicine and Health, The Back Pain Research Team, Sydney Musculoskeletal Health, The Kolling Institute, School of Health Sciences
Emma Ho
PainRelief.com: What is the background for this study?
Response: Adults with chronic low back pain (lasting for more than 12 weeks) not only experience physical disability but can also suffer psychological distress in the form of anxiety, depression, and fear avoidance (avoiding movement for fear of pain).
Clinical guidelines therefore consistently recommend a combination of exercise and psychosocial therapies for managing chronic low back pain. However, not much is known about the different types of psychological therapies available as well as their comparative effectiveness and safety, leaving doctors and patients often unclear about the best choice of treatment. Accordingly, the aim of our systematic review with network meta-analysis was to determine the comparative effectiveness and safety of psychological interventions for chronic non-specific low back pain.
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