Category Archives: Pain-Relief

Chronic Pain Sufferers Face Different Pain Triggers During Pandemic

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MedicalResearch.com Interview with:
Rubén Nieto
eHealth Lab Research Group,
Faculty of Health Sciences
Universitat Oberta de Catalunya
Barcelona, Spain

MedicalResearch.com:  What is the background for this study?

Response: The COVID-19 pandemic is one of the most serious global challenges to have faced healthcare and society in the last century, taking a drastic toll on the world’s population. It has caused deaths, worsened people’s quality of life and upended the economy, among other consequences. Despite this, there is little research on how people are coping with the pandemic. In our opinion, it is of particular interest to study people with chronic pain, since COVID-19 and the circumstances surrounding it can have a greater impact on them.

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Fibromyalgia: Evaluation of Pain Relief Therapies

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PainRelief.com Interview with:
VINÍCIUS CUNHA OLIVEIRA, PhD 
Departamento de Fisioterapia – UFVJM 
Brasil

Dr. Oliveira

PainRelief.com:  What is the background for this study?

Response: Fibromyalgia is a chronic health condition of unknown etiology characterized by generalized body pain, fatigue, sleep disturbance, impaired cognition, and anxiety. It causes disability, lowers quality of life and is responsible for with high direct and indirect costs. Many therapeutic options are available and delivered to these patients and it is important to patients and clinicians to understand the average effects sizes of these interventions in order to make their choices.

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Benefits of Psychedelics’ Microdosing May Be Explained by Placebo Effect

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PainRelief.com Interview with:|
Balázs Szigeti, PhD
Center for Psychedelic Research
Imperial College London

PainRelief.com:  What is the background for this study?  What are the main findings?

Response: The study investigated microdosing which is the regular intake of small doses of psychedelics drugs (e.g. LSD; a typical microdose is about 10-20% of recreational doses).  This study used a ‘self-blinding’ citizen science methodology, where participants, who microdosed on their own initiative using their own substance could participate online. Participants were given online instructions on how to incorporate placebo control into their microdosing routine without clinical supervision. The strength of this design is that it allowed us to obtain a large sample size while implementing placebo control at minimal logistic and economic costs.  The study was completed by 191 participants, making it the largest placebo-controlled trial on psychedelics to-date, for a fraction of a cost of a clinical study.

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NSAID Ibuprofen Arginate Provides More Rapid Pain Relief Than Standard Ibuprofen

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PainRelief.com Interview with:
Dr. Perez Cajaraville MD EDPM
Clinical Director Pain Unit
HM Hospitales
Madrid. Spain

Dr. Cajaraville

PainRelief.com:  What is the background for this study?

Response: The addition of L-arginine to the molecule of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), in the salt form of ibuprofen arginate has the rationale to enhance the absorption rate of the active S-(+) enantiomer of ibuprofen to achieve a rapid onset analgesic action. Despite availability of ibuprofen arginate in the market for many years, a comprehensive review of the evidence of the analgesic efficacy, tolerability and safety in different pain models has not been previously reported.

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Hand Arthritis: Supplement Did Not Provide Pain Relief

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PainRelief.com Interview with:
Xiaoqian Liu
Clinical research fellow (Wednesday/Thursday)
Rheumatology Department| Royal North Shore Hospital
Institute of Bone and Joint Research | Sydney Medical School

hand arthritis

PainRelief.com:  What is the background for this study?

Response: Hand osteoarthritis (HOA) is a prevalent joint disease, causing symptoms in up to 10% of the general adult population worldwide. Hand pain is the most common symptom in addition to functional disability and decreased quality of life. Due to the modest effects and/or potential harms, current traditional treatment such as exercise, non-inflammatories and analgesics frequently do not meet patients’ demand. More and more people are turning to complementary and alternative medicines for pain relief.

In our previous work, we identified four dietary supplements with promising treatment effects for relieving pain which are Boswellia serrata extract, curcumin, pine bark extract and methylsulfonylmethane (MSM). The hypothesis was that combining these supplements to generate an enhanced benefit for people with HOA. The aim of the RADIANT study was to investigate the efficacy and safety of a 12-week course of this supplement combination in people with painful HOA who were confirmed with the diagnosis on their hand x-ray.

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Omega-3 fatty Acid Supplementation May Reduce Muscle Soreness After Exercise-Induced Muscle Damage

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MedicalResearch.com Interview with:

Yvoni Kyriakidou, BSc, MSc, RD, ANutr, AFHEA 
Dietitian-Sports Nutritionist
Doctoral Researcher in Exercise Physiology
Translational Physiology Research Group
School of Life Sciences, University of Westminster, England, UK

Yvoni Kyriakidou

MedicalResearch.com: What is the background for this study?

Response: Exercise-induced muscle damage (EIMD) results in transient muscle inflammation, strength loss, muscle soreness and may cause subsequent exercise avoidance. Omega-3 (primarily found in oily fish) supplementation may minimise EIMD via its anti-inflammatory properties. However, its efficacy remains unclear.

In our study, we gave people omega-3 capsules three times a day for four weeks to build up their levels, or a matching placebo. They then took part in a very intense exercise aimed at causing severe muscle pain and physiologically safe muscle damage. We then measured blood levels of inflammation and muscle damage markers, physical pain and the ability of the participants to do forceful muscle contractions every day for the next three days.

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High and Low Intensity Weight Training May Reduce Pain From Knee Osteoarthritis

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PainRelief.com Interview with:
Stephen P. Messier, PhD
.B. Snow Biomechanics Laboratory
Department of Health and Exercise Science
Wake Forest University
Winston-Salem, North Carolina

Stephen P. Messier, PhD .B. Snow Biomechanics Laboratory Department of Health and Exercise Science Wake Forest University Winston-Salem, North Carolina
Dr. Messier

PainRelief.com:  What is the background for this study?  What are the main findings?

Response: Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis and whether it may worsen symptoms.

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Opioids Not Only Option for Pain Relief After Cesarean Delivery

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PainRelief.com Interview with:
Cristina Wood, MD
Obstetric and Fetal Anesthesiologist
Children’s Hospital Colorado

Dr. Wood

PainRelief.com:  What is the background for this study?  What are the main findings?

Response: ​We all know that opiate abuse is a national crisis, but also is one of the top causes of maternal mortality in the state of Colorado. At the Colorado Fetal Care Center at Children’s Hospital Colorado, we wanted to see what we could do to reduce the need for opiate medications after cesarean delivery. We started by using wound soakers to reduce the opiate requirement and demonstrated an almost 30% reduction in postoperative opiate use. Then, when the Society of Obstetric Anesthesia and Perinatology (SOAP) published guidelines for Early Recovery

After Cesarean (ERAC), we incorporated these into our practice to determine if these interventions would decrease the opiate requirements further. We were so pleased to see that we could further reduce the opiate need for our moms postoperatively. In fact, we reduced it by approximately 80%, with 1/3 of our patients never taking a single narcotic medication after cesarean delivery. 

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Back Pain Relief: Skin Impedance Measurements Can Help Identify Trigger Points

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PainRelief.com Interview with:
Giovanni Barassi PhD
Center for Physiotherapy, Rehabilitation and Reeducation
Center of Sports Medicine
“G.d’Annnunzio” University
Chieti, Italy

PainRelief.com:  What is the background for this study?

Response: Our research started with the observations made during standard clinical practice concerning the inefficiency of standard physiotherapeutic procedures used for pain relief in chronic nonspecific low back pain, a scourge of modern times, particularly in industrialized countries. Therefore, the need has arisen to search for new approaches in the evaluation and treatment of musculoskeletal problems.

Chronic low back pain is clinically manifest as the pain between rib margins and folds of the inferior gluteus muscle. It usually results from an incorrect lifestyle, typical of modern society having too little physical activity, too much psycho-physical stress, and poor management of body weight. On the background of osteopathic medicine, we developed a concept of the dysfunctional flow of body fluids as a plausible underlier of low back pain, referring by and large to spine bony structures.

It has been shown that alterations in afferent activity coming from visceral, structural, and emotional nociception converge in the same metamers of the spinal cord, resulting in information noise and jam. The final motor output of the reflex arc encompasses somatic, myofascial, and connective tissue responses, with the inevitably added influence of the autonomic nervous system. There also are studies demonstrating the importance of interpreting myofascial dysfunction, not as an isolated local phenomenon but rather as an expression of the central nervous activity. Therefore, a concept has been shaped of somatic and myofascial dysfunction, currently gaining increasing recognition among physicians, osteopaths, and physiotherapists, the professionals dealing with tissue and joint manipulation. The practical crux of the issue is the identification of the “major dysfunction” site, expressing the specific spinal information jam.

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No Decrease in Pain Relief With Less Opioids After Surgery

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PainRelief.com Interview with:
Ryan Howard, MD
Academic Development Time Year 1
Resident, General Surgery
University of Michigan

PainRelief.com:  What is the background for this study?

Response: Opioids are commonly prescribed to control pain after surgery, but they also carry significant risks such as overdose, long-term dependence, and diversion into the community. While some have advocated for decreasing or eliminating opioids from postoperative pain control regimens, others are concerned that this would lead to uncontrolled pain and dissatisfied patients. To study whether that’s true, we compared two groups of patients undergoing the same surgical procedures. One group received “opioid-sparing” prescriptions after surgery and the other group received “normal-sized” prescriptions.

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