NSAID Ibuprofen Arginate Provides More Rapid Pain Relief Than Standard Ibuprofen

PainRelief.com Interview with:
Dr. Perez Cajaraville MD EDPM
Clinical Director Pain Unit
HM Hospitales
Madrid. Spain

Dr. Cajaraville

PainRelief.com:  What is the background for this study?

Response: The addition of L-arginine to the molecule of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), in the salt form of ibuprofen arginate has the rationale to enhance the absorption rate of the active S-(+) enantiomer of ibuprofen to achieve a rapid onset analgesic action. Despite availability of ibuprofen arginate in the market for many years, a comprehensive review of the evidence of the analgesic efficacy, tolerability and safety in different pain models has not been previously reported.

PainRelief.com: What are the main findings?

Response: Salification of ibuprofen with arginine provides a protective action against gastric mucosal damage. Ibuprofen arginate provides a rapid and effective analgesic effect as peak plasma concentrations are reached at 15 to 30 min after administration as compared with 1.5-3 hours for standard ibuprofen. In different clinical scenarios characterized by acute pain, such as dental pain, dysmenorrhea, headache/migraine, and postoperative pain after major surgery, ibuprofen arginate has been shown to be very effective and well tolerated.

PainRelief.com: What should readers take away from your report?

Response: Clinicians should be aware that ibuprofen arginate is a very useful analgesic compound when rapid onset pain relief is required in the management of disorders, in which acute pain is the main clinical symptom.

PainRelief.com: What recommendations do you have for future research as a result of this work?

Response: It would be interesting to perform further meta-analysis to compare different NSAID and non-NSAID analgesic options in terms of fast analgesic effects in  acute pain

No applicable disclosures


Cajaraville JP. Ibuprofen Arginate for Rapid-Onset Pain Relief in Daily Practice: A Review of Its Use in Different Pain Conditions. J Pain Res. 2021 Jan 25;14:117-126. doi: 10.2147/JPR.S280571. PMID: 33531831; PMCID: PMC7846824.

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Last Updated on March 2, 2021 by PainRelief.com