Prof. Wei Wang Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China
PainRelief.com: What is the
background for this study?
Response: The burden of migraine is
substantial, resulting in considerable economic and social losses. The latest
Global Burden of Disease Study showed that 1.25 billion people had migraine in
2017. A significant number of patients are still not responding well to drug
therapy, or cannot tolerate the adverse effects of drugs, or have
contraindications, which can lead to low medication compliance, headache
chronification and acute medication overuse. Prophylactic drugs should be
recommended for migraineurs who have at least four headache days per month, but
only 13% of patients reported current use of preventive drugs. Besides,
ineffectiveness of and/or contraindications to migraine medication affect
10-15% of people with migraine. Hence, a need exists to investigate non-drug
Previous studies suggest that
acupuncture works particularly well on a range of pain disorders. However,
clinical evidence for the benefit of manual acupuncture for migraine
prophylaxis remains scarce. Appropriate placebo control settings and successful
blinding are two critical elements in addressing this challenge. Sham
acupuncture involving penetrating needles should be avoided in clinical trials.
Previous acupuncture research has often used penetrating sham acupuncture,
involving needling non-acupuncture points, needling irrelevant acupuncture
points, or superficial needling. However, whether the needle is inserted into
an acupuncture point or a non-acupuncture point, it could produce a
physiological effect. Comparisons between true acupuncture and sham acupuncture
might also be biased by unsuccessful blinding. To ensure an inert placebo
control and successful blinding, we recruited acupuncture-naive patients, using
non-penetrating sham acupuncture at heterosegmental non-acupuncture points as
the control, and designed the same procedures to perform the same rituals as
much as possible in the manual and sham acupuncture groups.
PainRelief.com Interview with: Chenchen Wang MD, MSc Professor of Medicine Tufts University School of Medicine Director, Center For Complementary And Integrative Medicine Division of Rheumatology Tufts Medical Center, Boston, MA
PainRelief.com: What is the
background for this study? What are the
Response: Chronic Musculoskeletal Pain is a complex disorder without effective treatment Acupuncture, originating in China more than 3,000 years ago, is one of the most popular sensory stimulation therapies. However, despite the fact that acupuncture is widely used for pain relief in a number of conditions including severe knee osteoarthritis, acute postoperative pain, musculoskeletal disorders, evidence of the effect of Chronic Musculoskeletal Pain relief is scarce.
Our study was to determine the efficacy of acupuncture for pain relief in this field.
PainRelief.com Interview with: Fanrong Liang MD and Ling Zhao PhD
Acupuncture and Tuina School Chengdu University of Traditional Chinese Medicine Chengdu, Sichuan, China
PainRelief.com: What is the background for this study?
Response: Chronic stable angina (CSA) is the cardinal symptom of myocardial ischemia and is associated with an increased risk of major cardiovascular events and sudden cardiac death. CSA affects with an average of 3.4 million people over 40 years of age each year. The most recent survey reported a CSA prevalence of 9.6% in China, making it a considerable burden on healthcare and medical costs, considering China’s large population base. Because of limited medical resources and lack of obvious improvement with percutaneous coronary intervention, Chinese clinicians choose traditional Chinese medicine (TCM) and acupuncture in addition to antianginal treatment for CSA. In China, acupuncture has been used as nonpharmacological treatment for several decades, especially to relieve myocardial ischemia symptoms, improve cardiac function, and prevent recurrence.
PainRelief.com Interview with: Jai N. Patel, PharmD, BCOP Chief, Pharmacology Research
Associate Professor, Division of Hematology/Oncology
Department of Cancer Pharmacology
Levine Cancer Institute Charlotte, NC 28204
PainRelief.com: What is the background for this study? What are the main findings?
Response: Pain is one of the most prevalent and burdensome symptoms affecting patients with cancer. Cancer-related pain is most commonly treated with opioid analgesics; however, nearly two-thirds of patients have inadequate pain relief and/or experience opioid-related side effects.
Furthermore, the fear of opioid abuse/addiction and toxicity deters some from prescribing opioids and reduces patient compliance. Thus, nonpharmacologic interventions such as acupuncture may be safer approaches to cancer-related pain. Randomized controlled trials suggest acupuncture reduces chronic neuropathic and postoperative pain in patients with cancer. It is unknown whether any patient characteristics predict post-acupuncture pain response.
We assessed acupuncture’s effectiveness for cancer-related pain, identified patient characteristics associated with pain response, and determined its effect on other concurrent cancer-related symptoms in palliative medicine outpatients. We identified significant benefits in pain scores immediately after the first treatment and across multiple treatments. Significant pain reduction was associated with higher baseline pain and more advanced disease stage.
We also identified significant changes in anxiety, depression, drowsiness, dyspnea, fatigue, nausea and well-being. Improvements in fatigue and depression also correlated with significant pain reduction after acupuncture.Continue reading →
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