PainRelief.com Interview with: Joshua (Shuki) Aviram PhD, R.N Prof. Meiri’s Laboratory of Cancer Biology and Cannabinoid Research Post doc Fellow Faculty of Biology Technion Institute of Technology – Haifa, Israel
PainRelief.com: What is the background for this study? Response:I am a RN by profession, and treating patients with opioids as the main solution to alleviate their pain, with many adverse effects, such as severe constipation made me looking for another solution.
I reviewed the literature and I noticed that there were few reviews that used the same clinical trials as their basis, reaching somewhat different conclusions. Therefore, I decided to conduct a systematic review and meta-analysis of all available randomized controlled trials (RCTs) at that time.
PainRelief.com Interview with: Amnon A. Berger, MD, PhD MD/PhD Program 2006-2017 The Hebrew University Hadassah Medical School Jerusalem, Israel Resident Physician (CA-1/PGY-2) and Loring Scholar Department of Anesthesiology, Critical Care and Pain Medicine Beth Israel Deaconess Medical Center, Boston, MA
PainRelief.com: What is the background for this study? What are the main findings?
Response: Fibromyalgia is a common disorder of chronic widespread pain. It has been estimated to affect 2-4% of the general population, though that number is likely an underestimate of the actual incidence. Outside of chronic pain, it also contributes to morbidity and disability because it affects sleep, causes cognitive impairment and psychiatric perturbations. Fibromyalgia is difficult to diagnose and even more difficult to treat.
Because the underlying causes – the etiology and pathophysiology at the base of this condition – are still largely unknown, it is harder to tailor specific treatments. There is evidence to support several modes of treatment, but truly high-level evidence exists only for physical exercise. Effective treatment depends on long term commitment and a multimodal approach by a multidisciplinary team.
Recently, with the rise of use in cannabis and CBD, both for medical and recreational use, evidence has emerged to support its use in fibromyalgia. While most of the evidence is not clear cut and not high enough evidence to support cannabis use, the evidence is overall positive and cannabis derivatives may be an effective choice as part of a multimodal treatment plan.
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