PainRelief.com Interview with: Alex BrysonPhD Professor of Quantitative Social Science UCL Social Research Institute University College London London
Prof. Bryson
PainRelief.com: What is the background for this study?
Response: The authors were concerned to know more about both the incidence of chronic pain and its implications for health, wellbeing and labour market prospects later in life. So we turned to a birth cohort study (The National Child Development Study) tracking all those born in Britain in a single week in 1958 through to age 62 to take a life-course approach.
PainRelief.com Interview with: Professor Kim BennellFAHM Barry Distinguished Professor | NHMRC Leadership Fellow Dame Kate Campbell Fellow Centre for Health Exercise and Sports Medicine Department of Physiotherapy Melbourne School of Health Sciences The University of Melbourne, Victoria Australia
PainRelief.com: What is the background for this study?
Response:Osteoarthritis is very common, and a major contributor to disability and decreased function. Exercise is a key treatment for osteoarthritis, but many people admit to not undertaking exercise. We investigated whether a free, online 12-week unsupervised yoga program (“My Joint Yoga”) could improve pain and function in people with knee osteoarthritis. Our team worked with yoga therapists, physiotherapists and people with lived experience of osteoarthritis to design an online yoga program tailored specifically to those with knee osteoarthritis.
PainRelief.com Interview with: Isaac M. Chiu PhD Associate Professor, Department of Immunology Harvard Medical School Boston, MA 02115
PainRelief.com: What is the background for this study?
Response: The gut is densely innervated by pain fibers and we know that pain is associated with gut-related diseases. However, it is not so clear how pain fibers talk to the gut lining and barrier. We were interested to see that pain fibers were very close by the epithelial cells that line the gut, and in particular the goblet cells that produce mucus. We were wondering if mucus could be regulated by pain. Mucus is a key protective barrier that keeps our gut healthy by keeping harmful substances as well as bacteria away from the gut wall.
PainRelief.com Interview with: Marian Wilson, PhD, MPH, RN, PMGT-BC Associate Professor Assistant Editor, Pain Management Nursing Washington State University College of Nursing
Dr. Wilson
PainRelief.com: What is the background for this study?
Response: People with opioid use disorder often experience withdrawal symptoms that can interfere with recovery success. Our team was interested in whether noninvasive home sensors could provide accurate information to detect overnight restlessness and sleep problems that could indicate opioid withdrawal for adults prescribed methadone for opioid use disorder.
PainRelief.com Interview with: Dr. Woojin Won KU-KIST Graduate School of Converging Science and Technology Korea University, Seoul Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon Republic of Korea
PainRelief.com: What is the background for this study?
Response: Rheumatoid arthritis is a chronic systemic autoimmune disease that mainly affects the joint, and 30-70% of patients have complained of psychiatric disorders such as depression and cognitive impairment. It was suggested that inflammation of the brain was the cause, but the detailed mechanism was unknown. Based on the previous studies, I hypothesized that neuroinflammation will affect astrocytes (star-shaped brain cells) and induce psychiatric disorders.
In addition, there have been clinical reports that inhibition of monoamine oxidases (MAOs), enzymes that catalyze the oxidation of monoamine, relieves pain and mood disorder symptoms of rheumatoid arthritis. However, it is difficult to find a study on MAO inhibitors and rheumatoid arthritis. The reason may be that although MAO consists of two types (MAO-A and MAO-B), several studies have used them without distinction.
PainRelief.com Interview with: Nicole Simunovic, MSc On behalf of the NO PAin Principal Investigators
PainRelief.com: What is the background for this study?
Response: Orthopaedic surgeons prescribe more opioids than any other type of surgeon in North America. Opioids have the potential to be highly addictive and can cause serious harm or even death if taken in excess. The goal of our clinical study was to determine if an opioid sparing approach to postoperative pain management was safe and effective in patients undergoing arthroscopic knee and shoulder surgery.
PainRelief.com Interview with: Vinod Dasa MD Professor of Clinical Orthopaedics Director of Research Louisiana State University Health
PainRelief.com: Would you describe cryoneurolysis?
Response: Cryoneurolysis is a specialized intense cold therapy technique that provides long-term pain relief without the use of any system drugs. The iovera° system has revolutionized the delivery of long term, drug-free pain relief by delivering a concentrated, targeted cold therapy through a handheld device. The iovera° treatment blocks targeted sensory nerves from sending pain signals. Small closed-end needles are inserted into the treatment region and a treatment cycle is performed until the nerve is blocked, providing pain relief until the nerve regenerates. The localized nerve blocks and targets peripheral nerves to temporarily stop pain signals for up to 90 days and provide immediate, long-lasting pain relief without the need for opioids. The iovera° treatment is used to treat specific nerves so the pain relief is focused only on the part of the body that is being treated.
PainRelief.com Interview with: Dr Clifford L Shelton Consultant Anaesthetist, Wythenshawe Hospital Senior Clinical Lecturer, Lancaster Medical School (Director of Simulation and Skills) Executive Editor, Anaesthesia Reports Deputy Chair of PCPIE, National Institute of Academic Anaesthesia Health Services Research Centre
Dr. Annie Pinder North West School of Anaesthesia, Health Education England North West, Manchester, UK
PainRelief.com: What is the background for this study?
Response: Inhaled nitrous oxide is the most commonly-used pain relief for labour in the UK – used by an estimated 77% of women in labour. However, it has a high ‘carbon footprint’ and depletes the ozone layer so healthcare organisations must take steps to reduce its release. Previous works have also noted high levels of nitrous oxide in the work environment of midwives working on labour ward, which can have health implications.
In Scandinavia, nitrous oxide ‘cracking’ technology has been used for several years to address these concerns and this has recently become available in the UK – however, there is little available effectiveness of the technology in the clinical workplace. We previously conducted a bench experiment to assess the ability of cracking technology to reduce ambient nitrous oxide concentrations under ideal circumstances and found a substantial improvement when the technology was in place. However, controlled experimental situations are not representative of real-life.
In this study we therefore aimed to assess whether ambient nitrous oxide levels would be reduced when the technology was implemented on the low-risk birth centre of a typical UK maternity hospital.
PainRelief.com Interview with: Maxwell C. K. Leung, Ph.D. Assistant Professor Systems Biology and Toxicology New College of Interdisciplinary Arts and Sciences Arizona State University, West Campus
PainRelief.com: What is the background for this study?
Response: Over 200 million Americans currently have legal access to medical cannabis, recreational cannabis, or both. Yet, cannabis remains an illicit Schedule 1 substance at the federal level. This limits the efforts of several federal agencies to regulate harmful contaminants – including pesticides, heavy metals, solvents, microbes, and fungal toxins – in cannabis.
PainRelief.com Interview with: Beth Wallace, M.D. M.Sc Associate Investigator, Center for Clinical Management Research Staff Physician, Rheumatology VA Ann Arbor Healthcare System Assistant Professor, Division of Rheumatology University of Michigan
Dr. Wallace
PainRelief.com: What is the background for this study?
Response: Arthritis and joint pain are common among older adults. We used data from the University of Michigan National Poll on Healthy Aging to understand how a national sample of older adults experiences and manages joint pain.
PainRelief.com: What are the main findings?
Response: Seventy percent of adults aged 50-80 report that they have joint pain. Three in five have a diagnosis of arthritis, including 30% who have a diagnosis of osteoarthritis (also called “wear and tear” or “bone on bone” arthritis).
Of those with joint pain, half said that it limited their usual activities, but about three in four said that they saw arthritis and joint pain as a normal part of aging that they could manage on their own.
More than half of all adults use over-the-counter pain relievers like non-steroidal anti-inflammatory drugs (Advil, Motrin, Aleve) for joint pain. One in ten used a prescription oral steroid, like prednisone. This is important because these medications can cause or worsen health conditions common in older people, such as high blood pressure and heart disease. More than a quarter of adults who used oral steroids for joint pain did not remember discussing the risks of these medications with their health care provider.
Ninety percent of those with joint pain used non-medication treatments, like exercise, massage, and splints and braces, to manage their symptoms. Most people who used these treatments found them to be very helpful.
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