Do NSAIDs Accelerate Progression of Knee Osteoarthritis?

PainRelief.com Interview with:
Dr Thomas Perry PhD| Postdoctoral Research Fellow
Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research 
Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences

Dr Thomas Perry PhD| Postdoctoral Research Fellow
Versus Arthritis Centre for Sport, Exercise and Osteoarthritis Research 
Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences
Dr. Perry

PainRelief.com:  What is the background for this study?

Response: Management of knee osteoarthritis (OA) is multi-factorial and routinely involves the use pharmacological interventions; with most medications aimed at alleviating painful symptoms and improving function.

Little is known of the long-term effects of such medications on the structural progression of radiographic knee OA. Through examining the relationship between pharmacological interventions and the disease pathway, this may, in turn, identify potential areas for disease-modifying treatment development.

PainRelief.com: What are the main findings?

Response: In current users of non-steroidal anti-inflammatory drugs (NSAIDs), radiographic medial minimum joint space width (mJSW) was reduced compared to current non-users.

PainRelief.com: What should readers take away from your report?

Response: Clinical trials are needed to examine the disease-modifying effects of medications, particularly NSAIDs, in radiographic knee osteoarthritis. 

No disclosures

Citation:

Thomas A Perry, Xia Wang, Michael Nevitt, Christina Abdelshaheed, Nigel Arden, David J Hunter, Association between current medication use and progression of radiographic knee osteoarthritis: data from the Osteoarthritis Initiative, Rheumatology, 2021;, keab059, https://doi.org/10.1093/rheumatology/keab059

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