PainRelief.com Interview with:
David Andreu, PhD
Professor of Chemistry
Department of Experimental & Health Sciences
Pompeu Fabra University
Barcelona Biomedical Research Park
PainRelief.com: What is the background for this study? What are the main findings?
Response: Background is the (earlier) finding of a cross-talk between CB1 and 5HT2A receptors (two GPCRs forming a heterodimer) that can be acted upon (disrupted) by peptides that allow to dissociate analgesic (CB1-mediated) from (unwanted) cognitive effects ( CB1/5HT2A heterodimer-mediated, memory impairment etc); this is reference 18 of our paper.Continue reading