Peptide May Allow Cannabis to Provide Pain Relief Without Unwanted Side Effects Interview with:
David Andreu, PhD
Professor of Chemistry
Department of Experimental & Health Sciences
Pompeu Fabra University
Barcelona Biomedical Research Park
Barcelona, Spain

Prof. David Andreu (right)
Maria Gallo,
(first author)
Prof. Rafael Maldonado  What is the background for this study?  What are the main findings?

Response: Background is the (earlier) finding of a cross-talk between CB1 and 5HT2A receptors (two GPCRs forming a heterodimer) that can be acted upon (disrupted) by peptides that allow to dissociate analgesic (CB1-mediated) from (unwanted) cognitive effects ( CB1/5HT2A heterodimer-mediated, memory impairment etc); this is reference 18 of our paper. What should readers take away from your report?

Response: Our study strongly suggests that, with combined administration with our peptide, the possibility exists of therapeutic intervention using cannabinoids to alleviate pain without the unwanted side effects What recommendations do you have for future research as a result of this work?

Response: Our study confirms that, when adequately designed and formulated, peptides (contrary to much prejudice in some medical and pharma circles) can be successfully converted from undruggable to druggable molecules Is there anything else you would like to add?

Response: Preclinical and early phase clinical studies (chronic pain, neuropathic etc) are currently under way and will be divulged when completed.


Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

Maria Gallo Estefanía Moreno Sira Defaus Antonio Ortega-Alvaro Angel Gonzalez Patricia Robledo Marco Cavaco Vera Neves Miguel A. R. B. Castanho Vicent Casadó Leonardo Pardo Rafael Maldonado, and David Andreu
J. Med. Chem. 2021, XXXX, XXX, XXX-XXX

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