Peptide May Allow Cannabis to Provide Pain Relief Without Unwanted Side Effects

PainRelief.com Interview with:
David Andreu, PhD
Professor of Chemistry
Department of Experimental & Health Sciences
Pompeu Fabra University
Barcelona Biomedical Research Park
Barcelona, Spain

Prof. David Andreu (right)
Maria Gallo,
(first author)
Prof. Rafael Maldonado

PainRelief.com:  What is the background for this study?  What are the main findings?

Response: Background is the (earlier) finding of a cross-talk between CB1 and 5HT2A receptors (two GPCRs forming a heterodimer) that can be acted upon (disrupted) by peptides that allow to dissociate analgesic (CB1-mediated) from (unwanted) cognitive effects ( CB1/5HT2A heterodimer-mediated, memory impairment etc); this is reference 18 of our paper.

PainRelief.com: What should readers take away from your report?

Response: Our study strongly suggests that, with combined administration with our peptide, the possibility exists of therapeutic intervention using cannabinoids to alleviate pain without the unwanted side effects

PainRelief.com: What recommendations do you have for future research as a result of this work?

Response: Our study confirms that, when adequately designed and formulated, peptides (contrary to much prejudice in some medical and pharma circles) can be successfully converted from undruggable to druggable molecules

PainRelief.com: Is there anything else you would like to add?

Response: Preclinical and early phase clinical studies (chronic pain, neuropathic etc) are currently under way and will be divulged when completed.

Citation:

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

Maria Gallo Estefanía Moreno Sira Defaus Antonio Ortega-Alvaro Angel Gonzalez Patricia Robledo Marco Cavaco Vera Neves Miguel A. R. B. Castanho Vicent Casadó Leonardo Pardo Rafael Maldonado, and David Andreu
J. Med. Chem. 2021, XXXX, XXX, XXX-XXX

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