Swedish Study Examines Risks of ASD/ADHD After Prescribed Opioids During Pregnancy

PainRelief.com Interview with:

Emma N. Cleary (she/her)
Clinical Psychology PhD Candidate
Developmental Psychopathology Lab
Indiana University Bloomington

PainRelief.com: What is the background for this study?

Response: Pain is common during pregnancy and one of the options for managing it is with prescribed opioid pain medications. When pregnant patients and their physicians try to make decisions about using these medications, there are often concerns about impacts on fetal development given that these medications cross the placenta.

Previous studies have identified associations between prenatal exposure to opioids pain medications and increased risk of neurodevelopmental disorders like autism spectrum disorder (ASD) and  attention-deficit/hyperactivity disorder (ADHD), but it is unclear whether this is causal.

Acupuncture Found Safe, Effective and Long Lasting for Chronic Lower Back Pain Relief

PainRelief.com Interview with:
Lynn L. DeBar, PhD, MPH
Center for Health Research Distinguished Investigator
Center for Health Research
Portland OR 97227
Kaiser Permanente

Dr. DeBar

PainRelief.com: What is the background for this study?

Response: The study was initiated in response to a call for applications from the National Institute of Complementary and Integrative Health (NCCIH) of the National Institutes of Health (NIH) that they put forward because of the Center for Medicare and Medicaid Services (CMS) interest in that time in considering acupuncture as a covered Medicare benefit for older adults with chronic low back pain.

While acupuncture for the treatment in chronic lower back pain had been well studied for broader adults, little had focused specifically on its effectiveness among older adults. CMS was particularly interested in acupuncture as a potentially safer and more effective treatment than medications like opioids for pain management among older adults.

Potent Synthetic Opioids Driving Current Overdose Crisis

PainRelief.com Interview with:
Shravani Durbhakula, MD, MPH, MBA
Associate Professor of Anesthesiology, 
Division of Pain Medicine 
Vanderbilt University School of Medicine 
Medical Director, Comprehensive Pain Service 
Vanderbilt University Medical Center 

Shravani Durbhakula, MD, MPH, MBA
Associate Professor of Anesthesiology, 
Division of Pain Medicine 
Vanderbilt University School of Medicine 
Medical Director, Comprehensive Pain Service 
Vanderbilt University Medical Center 
Dr. Durbhakula

PainRelief.com: What is the background for this study?

Response: Our study highlights the rapid rise of nitazenes—extremely potent and dangerous synthetic opioids—silently driving the current overdose crisis. Developed in the 1950s by a pharmaceutical company and never approved for clinical use, nitazenes are up to 20 times more potent than fentanyl and are undetectable with standard drug tests available in emergency rooms.

These opioids are often mixed into counterfeit pills or other street drugs, posing an unseen threat. Furthermore, nitazenes interact with opioid receptors in a unique way, increasing overdose risk, heightening respiratory depression, and accelerating tolerance development, which makes them even more dangerous for users.

University of Sydney Study Finds Brainstem Contains a Circuit that can Produce Pain Relief in Specific Body Parts

PainRelief.com Interview with:

Lewis Crawford, B.Sci (Hons), PhD
Postdoctoral associate
Neural Imaging Laboratory | Faculty of Medicine and Health
Brain and Mind Centre
THE UNIVERSITY OF SYDNEY 

Dr. Crawford

PainRelief.com: What is the background for this study?

Response: The overall aim of our research is to determine the functioning of analgesic circuits in individuals with chronic pain. If we can identify these circuits, we will then in a position to activate them to produce pain relief. One way to explore analgesic circuits in humans is through the use of placebo analgesia paradigms.

Adjusting Gait May Help Provide Pain Relief from Knee Osteoarthritis

PainRelief.com Interview with:

Valentina Mazzoli, Ph.D
Assistant Professor
Department of Radiology-CBI
Translational Research Building
NYU Grossman School of Medicine

Dr. Mazzoli

PainRelief.com: What is the background for this study? What are the main findings?

Knee osteoarthritis is a very common and painful condition that limits mobility and is a leading cause of disability worldwide. Unfortunately, there are no disease-modifying treatments available. Symptoms are usually managed with painkillers, and in the most severe cases, with knee replacement surgery?

In our study, we showed that subtly adjusting the angle of the foot during walking may be an easy, inexpensive way to reduce knee pain in people with early-stage osteoarthritis.

ICAHN Mount Sinai Analysis Suggests Women Should Be Careful About Using Acetaminophen During Pregnancy

PainRelief.com Interview with:
Diddier Prada, MD, Ph.D. 
Assistant Professor 
Institute for Health Equity Research
Department of Population Health Science and Policy 
Department of Environmental Medicine
Icahn School of Medicine at Mount Sinai 
New York City, NY, USA
https://scholars.mssm.edu/en/persons/diddier-prada

PainRelief.com: What is the background for this study?

Response: Earlier research has indicated that using acetaminophen (such as Tylenol) during pregnancy might increase the likelihood of children developing neurodevelopmental conditions like autism or ADHD.

Data shows that more than half of pregnant women rely on acetaminophen in some regions. Various well-conducted studies, including long-term group observations and case-comparison analyses, have identified a potential association, though some found no relationship, and a few even hinted at a possible protective effect. However, these studies often faced challenges, such as depending on mothers’ memory for usage data, failing to consider underlying reasons for taking the drug (e.g., illness or fever), or employing inconsistent approaches, which complicates drawing firm conclusions. By applying a transparent and consistent framework, the Navigation Guide methodology, to assess the studies’ quality, credibility, and evidence strength, we aimed to offer a more reliable overview than previous reviews.

Study Finds Gabapentin for Chronic Low Back Pain Associated with Increased Risk of Dementia

PainRelief.com Interview with:
Nafis B Eghrar,  MS4
Case Western Reserve University School of Medicine
Cleveland, Ohio

Nafis B Eghrar,  MS4
Case Western Reserve University School of Medicine
Cleveland, Ohio

PainRelief.com: What is the background for this study?

Response: Gabapentin has shown promise in treating nerve-related pain, and it has become a popular choice to treat chronic low back pain, despite limited evidence. Currently, there is a discrepancy on whether taking gabapentin increases a patient’s risk for developing dementia.

Our main findings were that gabapentin prescription was associated with an increased risk for dementia and mild cognitive impairment. This risk was pronounced in younger adults (age 18-64). Moreover, the incidence of dementia and mild cognitive impairment was higher in those prescribed gabapentin 12+ times compared to those prescribed gabapentin 3-11 times. 

Innovations in Diagnostic Imaging for Lower Back Pathologies

Diagnosing lower back conditions and pathologies continues to become more accurate and less intrusive, with recent innovations offering alternatives to the traditional MRI scan. Some conditions are easy to diagnose without technology, with trained doctors able to spot the telltale signs of conditions such as spondylolisthesis based on the patient’s symptoms. However, some issues are much harder to detect, which is why scientists are continuously improving diagnostic imaging solutions to detect hidden problems.

We’ll guide you through modern diagnostic imaging methods for identifying lower back pathologies, considering the advantages and limitations. By spotting conditions early, patients can avoid life-changing symptoms and receive treatment before invasive surgery is required. Surgery for severe spinal stenosis and spondylolisthesis brings many risks, but early diagnosis can significantly reduce the number of people who require such procedures.

Person lying on scanner

Diagnostic Imaging for Lower Back Conditions

There are a number of existing diagnostic imaging methods that have been used for many years, with some of these technologies more modern and more effective than others. Here’s a summary of existing methods.

  1. X-rays (Radiographs)

X-rays are the most basic and commonly used initial imaging method for lower back problems. They’re typically the first-line imaging for trauma, suspected fractures, or obvious structural abnormalities.

X-rays are best used for:

  • Bone fractures and alignment issues
  • Spondylolisthesis (vertebral slippage)
  • Degenerative changes in spine structure
  • Scoliosis and other spinal deformities
  • Osteoporosis-related compression fractures

X-rays are limited as they cannot visualize soft tissues like muscles, ligaments, or discs, and they are not effective at detecting early degenerative changes. They also only provide basic structural information, and there is a very small risk of radiation exposure.

Walking More May Reduce Risk of Chronic Low Back Pain

PainRelief.com Interview with:
Rayane Haddadj, PhD Candidate
Department of Public Health and Nursing
Norwegian University of Science and Technology

PainRelief.com: What is the background for this study?

Response: Low back pain is the leading cause of disability worldwide and accounts for the highest healthcare spending in the Unites States.

Given its widespread impact, identifying modifiable risk factors – those that can be addressed through public health policy and targeted interventions – is therefore of great importance for reducing the burden of this condition.

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Indiana University Study Finds Tylenol has Unexpected Effect on Endocannabinoids for Pain Relief

PainRelief.com Interview with:
Alex Straiker Ph.D.
Associate Research Scientist, Psychological and Brain Sciences
Adjunct Instructor, Psychological and Brain Sciences
Department of Psychological and Brain Sciences
Gill Institute for Neuroscience, Indiana University
Bloomington, IN 47405, USA

Alex Straiker

PainRelief.com: What is the background for this study?

Response: Acetaminophen has been used to relieve pain since the late 19th century and became available around the world during the 1950s and 1960s. In the United States, it’s known as Tylenol (introduced in 1955), while in most other countries it’s referred to as paracetamol.

It is considered generally safe and remains one of the most widely used medications in the world. However, it still contributes to a significant number of deaths due to liver failure. In fact, in many countries, acetaminophen-related toxicity is the leading cause of acute liver failure.

What’s surprising is that, despite its long history and widespread use, we still don’t fully understand how acetaminophen works.

Scientists have proposed several mechanisms of action involving serotonin pathways and cyclooxygenase (COX) enzymes.  Several lines of evidence point to the body’s natural cannabis-like chemicals, called endocannabinoids.

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