Posture and Pill Shape Affect How Quickly Pain Relief Medications Dissolve and Work What should readers take away from your report?

Response: Our simulations show that due to the asymmetric configuration of the stomach (the stomach exit is pointed towards to the right side of our bodies), staying upright and or lying on your right-side leads to more rapid dissolution as compared to lying on the back and especially compared to lying down on your left side. This is because when lying on the right side, gravity will tend to move the pills (which are slightly heavier than water) towards the part of the stomach where most of the mixing and grinding happens. What recommendations do you have for future research as a result of this study?

Response: We are examining the effect of pill shape, gastric disorders and gastric surgery on the dissolution of pills, as well as on the digestion of meals in the stomach.

Disclosures: We are funded by NIH and NSF.


J. H. Lee (이재호)S. KuharJ.-H. Seo (서정희)P. J. Pasricha, and R. Mittal 
“Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability”, Physics of Fluids 34, 081904 (2022)

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