Hypertension Drug May Decrease Both Inflammation and Need for Knee Replacement

PainRelief.com Interview with:

Iskandar Tamimi MD, PhD
Hospital Regional Universitario de Málaga
Faculty of Medicine, University of Málaga
Hospital HM
Málaga, Spain

PainRelief.com: What is the background for this study?

Response: Knee osteoarthritis is a painful and limitting condition that affects a significant percentage of the world’s population. The treatment of end stage knee osteoarthritis is a undergoing a total knee replacement. This procedure is considered a major surgery and it’s associated with a significant number of complications, such as infections, deep vein thrombosis, residual knee pain, etc,,

PainRelief.com: What are the main findings?

Response: On the other hand, β-blockers are a widely used type of medications, known to downregulate the adrenergic system. These drugs are mainly prescribed in patients with high blood pressure and other cardiovascular conditions. Recent research has shown that these drugs could also downregulate some of the inflammatory mediators involved in osteoarthritis. Therefore my colleagues and I believed that perhaps the use of β-blockers could also slow down the degenerative processes involved in osteoarthritis of the knee.

PainRelief.com: What should readers take away from your report?

Response: That the use of β-blockers could decrease the risk of undergoing a total knee replacement by 54%. If these drugs were taken for more than 5 years the protective effect increases to 64%. Therefore, we believe that these drugs could benefit patients who suffer from hypertension and knee osteoarthritis. However, this study cannot draw conclusions regarding the “true causal link” between β-blocker treatment and the risk of undergoing a total knee replacement.  Yet this study provides a hypothesis for the development of future therapeutic lines targeting the adrenergic system in the treatment of osteoarthritis.

PainRelief.com: What recommendations do you have for future research as a result of this study?

Response: Future research could focus on understanding the relation between the adrenergic system and osteoarthritis.


Tamimi, Iskandar MD, PhD1,2,3,a; García-Meléndez, Gaspar MD1; Vieitez-Riestra, Ignacio MD1; Palacios-Penedo, Sergio MD1; Garceso, Diego Moriel MD1; Sanchez, Alejandro MD1; Tamimi, Faleh PhD4; Guerado, Enrique MD, FRCS, PhD2,5; Milner, Marc Stefan Dawid MD, PhD2; de Quevedo, David Garcia MD1; Gonzalez-Quevedo, David MD, PhD1. The Use of β-Blockers and the Risk of Undergoing a Knee Arthroplasty: A Nested Case-Control Study. The Journal of Bone and Joint Surgery ():10.2106/JBJS.22.01189, September 5, 2023. | DOI: 10.2106/JBJS.22.01189


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Last Updated on September 9, 2023 by PainRelief.com