PainRelief.com: What are the main findings?

Response: Our results showed that after three months of implantation in rabbit knees, notable signs of repair of articular cartilage as well as oesteochonral bone were observed, with no hydrogel remaining and no rejection of the implant by the animals’ immune system.

Our work opens a new approach to engineer biomechanically compatible scaffolds for cartilage regeneration.  

PainRelief.com: What should readers take away from your report?

Response: Our study demonstrated the feasibility to engineering biomechanically compatible scaffolds for cartilage repair. This work has the potential to allow for engineering new scaffolds with much improved efficacy for cartilage repair.

PainRelief.com: What recommendations do you have for future research as a result of this study?

Response: Our work will enable researchers to systematically investigate the interplay between biomechanical and biochemical cues in cartilage repair, and in turn help optimize multiple cues simultaneously in hydrogel scaffolds to improve cartilage repair efficacy.

No disclosures

Citation:

Fu, L., Li, L., Bian, Q. et al. Cartilage-like protein hydrogels engineered via entanglement. Nature 618, 740–747 (2023). https://doi.org/10.1038/s41586-023-06037-0

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Last Updated on July 1, 2023 by PainRelief.com