Ebru Oral, PhD Associate Professor, Orthopaedic Surgery Associate Director, Harris Orthopaedic Laboratory Massachusetts General Hospital, Boston, MA, Harvard Medical School, Cambridge, MA
PainRelief.com: What is the background
for this study? What are the main
Response: This study focuses on the possibility of delivering analgesics from the polymeric implant surfaces used in total joint arthroplasty. Currently, there are multi-modal regimens for controlling pain during and after surgery, including peri-articular injections and systemic medications.
The study shows that it is possible to accomplish the delivery of the commonly used drug bupivacaine from the implants at relevant concentrations. The long-term goal is to provide this material as a tool in controlling pain locally so that the use of systemic opioid medications can be decreased.
PainRelief.com Interview with: Christine S. Cocanour, M.D., F.A.C.S., F.C.C.M. Division of Trauma, Acute Care Surgery and Surgical Critical Care UC Davis Health
PainRelief.com: What is the
background for this study?
Response:Our critical care pharmacists (Duby, Hamrick and Lee) and surgeons (Cocanour, Beyer) wanted to decrease our use of opioids without compromising pain control in our trauma patients—especially those that were admitted to the ICU. To help make more appropriate choices we put together an order set that was a multimodal approach to pain management.
MedicalResearch.com Interview with:
Michael Perloff, MD PhD
Assistant Professor of Neurology
Interventional Pain Management
Boston University School of Medicine
MedicalResearch.com: What is the background for this study? What are the main findings?
Response: Low back pain is very common. Patients with chronic low back pain that does not benefit from physical therapy, medications, or injections, often get spine surgery. If surgery fails to help (Failed back surgery syndrome-i.e. continued low back and leg pain after surgery), options for pain relief become more complex.
Typically, patients with failed low back surgery syndrome have tried complex procedures, repeat surgery or technology implants as their main options.
The SEAL procedure is a shortened, simple procedure (done in about 20 minutes) that can help as treatment for failed back surgery symptoms. In the published case series of 30 patients, some patients achieved very good, sustained, pain relief. Continue reading →